id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-293640-pgrrurrc	Tripathi, Satyendra C	Renal carcinoma is associated with increased risk of coronavirus infections	2020-07-06		.txt	text/plain	3724	202	48	We took a bioinformatics approach to analyze the gene and protein expression data of these coronavirus receptors in human normal and cancer tissues of multiple organs. TCGA data analysis also showed increased expression of all receptors except TMPRSS2 in renal tumor tissues as compared to their adjacent normal (Sup Fig 1) . Further, we specifically analyzed ACE2, which is a primary SARS-CoV receptor and DPP4, highly correlated to ACE2 across the kidney cancer subtypes along with immune cell signatures (innate and adaptive immunity, inflammatory cytokines and chemokines). ACE2, DPP4, ANPEP, and ENPEP each associated with a high level of immune infiltration, inflammatory chemokines, cytokines and markers of an immunosuppressive microenvironment and T cell exhaustion in KIRC tumors. The Tumor Immune System Interaction database (TISIDB) (http://cis.hku.hk/TISIDB/) platform was used to analyze the correlation of ACE2 with other CoV receptors (DPP4, ANPEP, ENPEP, TMPRSS2) expression in different renal carcinoma subtypes.	./cache/cord-293640-pgrrurrc.txt	./txt/cord-293640-pgrrurrc.txt