id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-294120-8fxrqorg	Guebre-Xabier, Mimi	NVX-CoV2373 vaccine protects cynomolgus macaque upper and lower airways against SARS-CoV-2 challenge	2020-08-19		.txt	text/plain	866	78	64	title: NVX-CoV2373 vaccine protects cynomolgus macaque upper and lower airways against SARS-CoV-2 challenge Cynomolgus macaques (Macaca fascicularis) immunized with NVX-CoV2373 and the saponin-based Matrix-M adjuvant induced anti-S antibody that was neutralizing and blocked binding to the human angiotensin-converting enzyme 2 (hACE2) receptor. And, hACE2 receptor 158 inhibition titers of 649, 1,410, and 1,320 in 2.5, 5, and 25 µg NVX-CoV2373 dose groups 159 respectively were 5.2 -11.2-fold higher than in convalescent sera ( Figure 1C) . Finally, 160 SARS-CoV-2 GMT neutralization antibody titers of 17,920 -23,040 CPE 100 in 161 immunized macaques, were 7.9 -10.1-fold higher than in convalescent sera ( Figure 162 1D) . To evaluate the potential efficacy of NVX-CoV2373 vaccine, macaques were 165 challenged with SARS-CoV-2 virus in upper and lower airways. SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 214 elicits immunogenicity in baboons and protection in mice These interests do not alter the authors adherence to policies on 209 sharing data and materials.	./cache/cord-294120-8fxrqorg.txt	./txt/cord-294120-8fxrqorg.txt