id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-295257-iguhy1z8	Calcagnile, Matteo	ACE2 polymorphisms and individual susceptibility to SARS-CoV-2 infection: insights from an in silico study	2020-04-24		.txt	text/plain	4785	253	49	SARS-CoV-2 and respiratory syndrome corona virus (SARS-CoV) Spike proteins share very high phylogenetic similarities (99%), and, indeed, both viruses exploit the same human cell receptor namely angiotensin-converting enzyme 2 (ACE2), a transmembrane enzyme whose expression dominates on lung alveolar epithelial cells 6, 15, 16 . In this study we have used a combination of in silico tools to analyze the possible impact of ACE2 single-nucleotide polymorphisms (SNPs) on the interaction with SARS-CoV-2 Spike glycoprotein. Results indicate that some residues of the ACE2 interface, which are involved in the interaction with SARS-CoV-2 Spike glycoprotein can actually fluctuate (Fig. 5cd ). Indeed, in the rodent blockade of the renin-angiotensin-aldosterone system limits the acute lung injury induced by the SARS-CoV-1 spike protein 49 , suggesting that if ACE2 function is preserved (because of increased baseline expression, as especially seen in pre-menopausal women), clinical course of infection might be less severe.	./cache/cord-295257-iguhy1z8.txt	./txt/cord-295257-iguhy1z8.txt