id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-300783-pvn2qq0f	Sadykov, Mukhtar	Short sequence motif dynamics in the SARS-CoV-2 genome suggest a role for cytosine deamination in CpG reduction	2020-08-07		.txt	text/plain	933	91	61	title: Short sequence motif dynamics in the SARS-CoV-2 genome suggest a role for cytosine deamination in CpG reduction RNA viruses use CpG reduction to evade the host cell defense, but the driving mechanisms are still largely unknown. Remarkably, by simply ordering SARS-CoV-2 genomes by their date of collection, we find a progressive increase of C-to-U substitutions resulting in 5'-UCG-3' motif reduction that in turn have reduced the CpG frequency over just a few months of observation. Our results thus link the dynamics of target sequences in the viral genome for two known host molecular defense mechanisms, mediated by the APOBEC and ZAP proteins. One such 34 mechanism is the CpG dinucleotide reduction observed in many single-stranded RNA 35 fraction of the observed C>U changes represent multiple, independent events ( Figure S3 ). CpG Dinucleotides in SARS-CoV-2 Extreme genomic CpG deficiency in SARS-CoV-2 and evasion of host 396 antiviral defense Multi-site co-398 mutations and 5'UTR CpG immunity escape drive the evolution of SARS-CoV-2	./cache/cord-300783-pvn2qq0f.txt	./txt/cord-300783-pvn2qq0f.txt