id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-300847-ycuiso0g	Li, Wei	Rapid selection of a human monoclonal antibody that potently neutralizes SARS-CoV-2 in two animal models	2020-06-02		.txt	text/plain	2801	172	55	We identified panels of fully human monoclonal antibodies (mAbs) from eight large phage-displayed Fab, scFv and VH libraries by panning against the receptor binding domain (RBD) of the SARS-CoV-2 spike (S) glycoprotein. By using phage display we have previously identified a number of potent fully human mAbs (m396, m336, m102.4) against emerging viruses including severe acute respiratory syndrome coronavirus (SARS-CoV) (4) , Middle East respiratory syndrome coronavirus (MERS-CoV) (5) and henipaviruses (6, 7) , respectively, which are also highly effective in animal models of infection (8) (9) (10) (11) ; one of them was administered on a compassionate basis to humans exposed to henipaviruses and successfully evaluated in a clinical trial (12) . Thus, to generate high affinity and safe mAbs we used eight very large (size ~ 10 11 clones each) naive human antibody libraries in Fab, scFv or VH format using PBMCs from 490 individuals total obtained before the SARS-CoV-2 outbreak.	./cache/cord-300847-ycuiso0g.txt	./txt/cord-300847-ycuiso0g.txt