id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-304544-tqtdjh2m	Enes, Ak	Transcriptional response of signalling pathways to SARS-CoV-2 infection in normal human bronchial epithelial cells	2020-06-20		.txt	text/plain	3745	189	49	Comparison of transcriptome of NHBE cells 24 hours after mock-infection and SARS-CoV-2 infection demonstrated that most genes that respond to infection were upregulated (320 genes) rather than being downregulated (115 genes).While upregulated genes were enriched in signalling pathways related to virus response, downregulated genes are related to kidney development. Although virus entry protein ACE2 has low expression in NHBE cells, pathogen response pathways are strongly activated within 24 hours of infection. Upregulated MMPs and chemokines demonstrate the response generated by NHBE cells to trigger the immune system, these two subgroups of genes are further discussed below comparatively in SARS-CoV-2 and H1N1 infection. Interestingly, none of the IL-17 ligands were expressed in detectable amounts in NHBE cells, and none of the ligands or receptors were upregulated in response to virus infection, therefore the positive feedback loop is likely to be initiated by activation of NFκB via other signalling pathways.	./cache/cord-304544-tqtdjh2m.txt	./txt/cord-304544-tqtdjh2m.txt