id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-306901-uuwgpuhw	Roy, Sylvie	Efficient production of Moloney murine leukemia virus-like particles pseudotyped with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spike protein	2020-09-16		.txt	text/plain	4215	251	58	title: Efficient production of Moloney murine leukemia virus-like particles pseudotyped with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spike protein Several investigational vaccines that have already been tested in animals and humans were able to induce neutralizing antibodies against the SARS-CoV-2 spike (S) protein, however protection and long-term efficacy in humans remain to be demonstrated. We have investigated if a virus-like particle (VLP) derived from Moloney murine leukemia virus (MLV) could be engineered to become a candidate SARS-CoV-2 vaccine amenable to mass production. High amounts of SARS-CoV-2 DS protein are incorporated into MLV VLPs released 142 from stable producer cells. A VLP-derived SARS CoV-2 vaccine will be a viable option if 143 sufficient amounts of S protein are incorporated at the surface of the released particles. In conclusion, we have developed and characterized a new MLV VLP platform that can 243 efficiently incorporate the S protein from SARS-CoV-2, and that has the potential to produce a pan-244 coronavirus vaccine.	./cache/cord-306901-uuwgpuhw.txt	./txt/cord-306901-uuwgpuhw.txt