id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-306924-dw35dlx3	Wohlers, Inken	COVID-19 risk haplogroups differ between populations, deviate from Neanderthal haplotypes and compromise risk assessment in non-Europeans	2020-11-03		.txt	text/plain	798	59	54	title: COVID-19 risk haplogroups differ between populations, deviate from Neanderthal haplotypes and compromise risk assessment in non-Europeans Recent genome wide association studies (GWAS) have identified genetic risk factors for developing severe COVID-19 symptoms. We show that (i) COVID-19-related genetic factors of Neanderthals deviate from those of modern humans and that (ii) they differ among world-wide human populations, which compromises risk prediction in non-Europeans. Currently, caution is thus advised in the genetic risk assessment of non-Europeans during this world-wide COVID-19 pandemic. However, as two positions carry protective alleles the risk probability of the 51 previously assessed Vindija Neanderthal haplotype is only 52%. 82 83 All human risk haplogroups differ from Neanderthal haplotypes (Fig. 1c) If this variant was causal (2% probability) using lead variants such as rs11385942 or 120 rs35044562 would incorrectly classify individuals carrying these haplogroups to be at 121 risk. The major genetic risk factor for severe COVID-19 is 142 inherited from Neanderthals	./cache/cord-306924-dw35dlx3.txt	./txt/cord-306924-dw35dlx3.txt