id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-307701-fujejfwb	Gaurav, Shubham	Identification of unique mutations in SARS-CoV-2 strains isolated from India suggests its attenuated pathotype	2020-06-07		.txt	text/plain	2069	111	54	Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), which was first reported in Wuhan, China in November 2019 has developed into a pandemic since March 2020, causing substantial human casualties and economic losses. In this study, we sequenced and analyzed the genomic information of the SARS-CoV-2 isolates from two infected Indian patients and explored the possible implications of point mutations in its biology. Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the cause of the novel human Corona Virus Disease COVID-19, first reported on November 17 th , 2019 in Wuhan, China [12] . In addition to structural and NSPs, SARS-CoV-2 genome also codes for at least two other viroporin candidates (other than the E protein), namely ORF3a and ORF8 [3] . Moreover, the 29-nucleotide deleted SARS CoV-1 strain had a 23-fold less viral replication as compared to its wild type, suggesting that this mutation effectively attenuated the virus.	./cache/cord-307701-fujejfwb.txt	./txt/cord-307701-fujejfwb.txt