id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-307811-6e3j0pn7	Hao, Wei	Binding of the SARS-CoV-2 Spike Protein to Glycans	2020-07-02		.txt	text/plain	5665	299	54	Infection normally starts with the attachment of the virus to cell-surface glycans like heparan sulfate (HS) and sialic acid-containing oligosaccharides. Previous studies of many other viruses suggested that SARS-CoV-2 S protein may use other molecules on host cell surface as attachment factors to facilitate binding to the high-affinity receptor ACE2. 36 A recent study suggested that HS may bind to the receptor binding domain (RBD, the C-terminal region of the S1 subunit, Fig. 2 ) of the SARS-CoV-2 spike protein and change its conformation. 38 In this study, we systematically examined and compared the binding of the SARS-CoV-2 S protein subunits, full-length molecule and its trimer to different HS using microarray experiments (Fig. 2) . In addition to binding protein-based receptors, many viruses can interact with cell surface glycans, including GAGs and sialic acid-containing oligosaccharides.	./cache/cord-307811-6e3j0pn7.txt	./txt/cord-307811-6e3j0pn7.txt