id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-309411-2dfiwo65	Paris, Kristina A.	Loss of pH switch unique to SARS-CoV2 supports unfamiliar virus pathology	2020-06-23		.txt	text/plain	4728	256	58	On the other hand, the loss of this pH-switch, which sequence alignments show is unique to CoV2, eliminates the transition state and allows the virus to stay bound to the ACE2 receptor for time scales compatible with the recruitment of additional ACE2 receptors diffusing in the cell membrane. Work on SARS-CoV (CoV1) has already determined that the virus enters cells via receptormediated endocytosis in a pH-dependent manner (Wang et al., 2008) that is characterized by cotranslocation of the viral spike glycoprotein and its specific functional receptor, the angiotensinconverting enzyme 2 (ACE2), from the cell surface to early endosomes. This newly discovered difference in protein sequence in the receptor binding domain of the spike glycoprotein and its impact on receptor binding reveals a mechanism that allows SARS-CoV2 internalization to take advantage of the high expression of ACE2 in the nasal epithelium¾resulting in increased retention times in the upper respiratory tract and augmented infectivity.	./cache/cord-309411-2dfiwo65.txt	./txt/cord-309411-2dfiwo65.txt