id author title date pages extension mime words sentences flesch summary cache txt cord-309556-xv3413k1 Chow, Ryan D. The aging transcriptome and cellular landscape of the human lung in relation to SARS-CoV-2 2020-04-15 .txt text/plain 5761 373 53 In aggregate, these analyses showed that the age-associated genes with functional roles in SARS-CoV are expressed in specific cell types of the human lung. Of note, the overlap between lung ageassociated genes and SARS-CoV-2 regulated genes was statistically significant across all 3 cell lines (Figure 6d-f) , suggesting a degree of similarity between the transcriptional changes associated with aging and with SARS-CoV-2 infection. Among the age-associated genes that were induced by SARS-CoV-2 infection, the majority of these genes increase in expression with age (Cluster 1) (Figure 6g-i) . To identify a consensus set of age-associated genes that are regulated by SARS-CoV-2 infection, we integrated the analyses from all 3 cell lines. By integrating these data with single cell transcriptomes of human lung tissue, we further pinpointed the specific cell types that normally express the age-associated genes. ./cache/cord-309556-xv3413k1.txt ./txt/cord-309556-xv3413k1.txt