id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-310477-vniokol0	Pontes, Camila	Unraveling the molecular basis of host cell receptor usage in SARS-CoV-2 and other human pathogenic β-CoVs	2020-08-21		.txt	text/plain	4371	197	46	More precisely, our results indicate that host cell receptor usage is encoded in the amino acid sequences of different CoV spike proteins in the form of a set of specificity determining positions (SDPs). In summary, the SDPs found within these β-CoV subgenera define a specific region of the receptor binding domains: they are part of, or in direct contact with, the ACE2 interacting surface ( A second S3Det analysis was performed on the full β-CoV MSA. On the other hand, the analysis performed on individual β-CoV subgenera, i.e. Sarbecovirus, Merbecovirus and Embecovirus subgroups, allowed a fine-grained classification into subfamily clusters that clearly reflect the functional diversification of the spike protein family, that is, the specificity to different host-cell receptors (Figure 2-3) .	./cache/cord-310477-vniokol0.txt	./txt/cord-310477-vniokol0.txt