id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-310752-zl2g9wqo	Sato, Taku	Expression of ACE2 and TMPRSS2 proteins in the upper and lower aerodigestive tracts of rats	2020-05-15		.txt	text/plain	2135	119	48	Methods To elucidate the underlying histological mechanisms of the aerodigestive disorders caused by SARS-CoV-2, we investigated the expression of ACE2 and TMPRSS2 proteins in the aerodigestive tracts of the tongue, hard palate with partial nasal tissue, larynx with hypopharynx, trachea, esophagus, lung, and kidney of rats through immunohistochemistry. Results Strong co-expression of ACE2 and TMPRSS2 proteins was observed in the nasal respiratory epithelium, trachea, bronchioles, alveoli, kidney, and taste buds of the tongue. Notably, strong co-expression of ACE2 and TMPRSS2 proteins was observed in the taste buds of the tongue, nasal respiratory epithelium, trachea, bronchioles, alveoli, and the kidney. The strong co-expression of ACE2 and TMPRSS2 in the taste buds may explain the high incidence of ageusia or dysgeusia in patients with SARS-CoV-2 infection. Unlike that in the nasal respiratory epithelium, TMPRSS2 was more strongly expressed in the cytoplasm of tracheal epithelium, hence suggesting the trachea to be more prone to developing clinical symptoms after SARS-CoV-2 infection than the nasal tissue.	./cache/cord-310752-zl2g9wqo.txt	./txt/cord-310752-zl2g9wqo.txt