id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-311445-b6bc6vwd	Bansal, Kanika	Codon pattern reveals SARS-CoV-2 to be a monomorphic strain that emerged through recombination of replicase and envelope alleles of bat and pangolin origin	2020-10-12		.txt	text/plain	2749	169	60	Systematic analysis of CUP of replicase (rdrp), spike, envelope (E), membrane glycoprotein (M), and nucleocapsid (N) encoding genes of SARS-CoV-2 from reported diverse lineages to suggest one-time host jump of a SARS-CoV-2 isolate into the human host. In contrast to human isolates, a high degree of variation in CUP of these genes suggests that bats, pangolins, and dogs are natural reservoirs of diverse strains. In the present study, we have focused on codon usage pattern (CUP) of SARS coronavirus from different hosts under debate (bat, pangolin, and dog) as a probable origin for SARS-CoV-2. However, another study comparing the codon usage pattern of SARS-CoV-2 with other betacoronaviruses suggested that current pandemic coronavirus is subjected to different evolutionary pressures (Gu et al., 2020) . The above analysis reveals single patterns for all five genes in different lineages of SARS-CoV-2 affirms a single event of host jump of codon-optimized SARS strain from its animal reservoir.	./cache/cord-311445-b6bc6vwd.txt	./txt/cord-311445-b6bc6vwd.txt