id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-312305-ll29frwc	Sun, Shihui	Characterization and structural basis of a lethal mouse-adapted SARS-CoV-2	2020-11-11		.txt	text/plain	4720	270	52	Herein, we generated and characterized a novel mouse-adapted SARS-CoV-2 strain named MASCp36 that causes acute respiratory symptoms and mortality in standard laboratory mice. We further characterized the in vivo replication dynamics of MASCp6 in both young and aged mice, and the results from qRT-PCR showed that high levels of SARS-CoV-2 subgenomic RNAs were persistent in the lung and tracheas till 4 day post infection (dpi) in aged mice (Fig. 1E) . The skewed age distribution of COVID-19 disease was reproduced in the MASCp36 infected mouse model where more severe symptoms were observed in aged mice when compared to young mice. In addition to the age-related skewed distribution of COVID-19, gender-related differences in distribution of COVID-19 disease is also recapitulated in this MASCp36 infected mouse model with increased susceptibility and enhanced pathogenicity observed in male mice when compared to their female counterparts.	./cache/cord-312305-ll29frwc.txt	./txt/cord-312305-ll29frwc.txt