id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-312702-fruzsn26	Finch, Courtney L.	Characteristic and quantifiable COVID-19-like abnormalities in CT- and PET/CT-imaged lungs of SARS-CoV-2-infected crab-eating macaques (Macaca fascicularis)	2020-05-14		.txt	text/plain	2785	167	46	title: Characteristic and quantifiable COVID-19-like abnormalities in CTand PET/CT-imaged lungs of SARS-CoV-2-infected crab-eating macaques (Macaca fascicularis) Based on the rather limited X-97 ray findings in the lungs of reported NHP models of SARS-CoV-2 infection with either 98 mild or no clinical signs (11, 25, 27-29), we turned to high-resolution chest CT and 99 Increases in PCLH or PCLH/LV 169 were not seen in the mock-exposed macaques over the entire study (Figure 8a A key advantage of quantifiable CT chest imaging readout over serial euthanasia 212 studies, in addition to potentially reduced experimental animal numbers, is the ability not 213 only to evaluate between-group differences, but also to compare severity and duration of 214 disease at higher resolution in single animals and even in isolated parenchymal areas 215 sequentially. follow-up confirmation of these pilot results in this model of mild-moderate COVID-19 233 is needed to further establish quantifiable lung CT as a reliable disease readout and to 234 forge imaging-pathologic correlates in macaques euthanized at peak radiographic 235 abnormality.	./cache/cord-312702-fruzsn26.txt	./txt/cord-312702-fruzsn26.txt