id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-312999-3erodkv9	Hassan, Sk. Sarif	Notable sequence homology of the ORF10 protein introspects the architecture of SARS-COV-2	2020-09-06		.txt	text/plain	3920	236	53	SARS-CoV-2 has been reported to be uniquely characterized by the accessory protein ORF10, which contains eleven cytotoxic T lymphocyte (CTL) epitopes of nine amino acids length each, across various human leukocyte antigen (HLA) subtypes. In this study, all missense mutations found in sequence databases were examined across twnety-two unique SARS-CoV-2 ORF10 variants that could possibly alter viral pathogenicity. The high degree of physicochemical and structural similarity of ORF10 proteins of SARS-CoV-2 and Pangolin-CoV open questions about the architecture of SARS-CoV-2 due to the disagreement of these two ORF10 proteins over their sub-structure (loop/coil region), solubility, antigenicity and change from the strand to coil at amino acid position 26, where tyrosine is present. Based on the mutations, conserved and non-conserved residues in ORF10 proteins are identified and marked in different colors in (Figure There are altogether 22 distinct missense mutations which were examined across 22 unique ORF10 variants of SARS-CoV-2.	./cache/cord-312999-3erodkv9.txt	./txt/cord-312999-3erodkv9.txt