id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-315702-pn8247j2	Sahakijpijarn, Sawittree	Development of Remdesivir as a Dry Powder for Inhalation by Thin Film Freezing	2020-09-22		.txt	text/plain	2300	139	48	Remdesivir exhibits in vitro activity against SARS-CoV-2 and was granted approval for Emergency Use. To maximize delivery to the lungs, we formulated remdesivir as a dry powder for inhalation using thin film freezing (TFF). In conclusion, TFF technology produces high potency remdesivir dry powder formulations for inhalation suitable to treat patients with COVID-19 on an outpatient basis and earlier in the disease course where effective antiviral therapy can reduce related morbidity and mortality. Although several techniques have been used to prepare inhalable powders, including 116 mechanical milling and spray drying, the advantages of thin film freezing (TFF) over other techniques 5 of 39 rely on the ability to produce aerosolizable particles composed of brittle matrix, nanostructured 118 aggregates. This shows that the 530 TFF technology can be used to minimize the need of excipient(s) in the formulation, thus maximizing 531 the amount of remdesivir being delivered to the lungs by dry powder inhalation.	./cache/cord-315702-pn8247j2.txt	./txt/cord-315702-pn8247j2.txt