id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-319447-xanewi59	Sun, Jiya	Comparative transcriptome analysis reveals the intensive early-stage responses of host cells to SARS-CoV-2 infection	2020-05-01		.txt	text/plain	3250	163	52	To gain insights, we performed high-throughput sequencing that generated time-series data simultaneously for bioinformatics analysis of virus genomes and host transcriptomes implicated in SARS-CoV-2 infection. The early rapid host responses were potentially attributed to the high efficiency of SARS-CoV-2 entry into host cells, underscored by evidence of a remarkably up-regulated gene expression of TPRMSS2 soon after infection. In this study, we used the SARS-CoV-2 strain isolated from patients [11] to infect in vitro Calu-3 cells, and performed RNA sequencing to determine the time-series transcriptome profiling data of the host. Next, to gain possible explanations for the distinct patterns in host antiviral capacity and cytokine production during SARS-CoV-2 infection, dynamic expression of four types of key genes were evaluated, including virus receptors for cell entry, pathogen recognition receptors (PRRs) for an innate immune startup, regulator genes for induction of antiviral-related genes and interferon production (Figure 4) .	./cache/cord-319447-xanewi59.txt	./txt/cord-319447-xanewi59.txt