id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-321050-yabt72jf	Tuttle, Kathryn D.	JAK1 inhibition blocks lethal sterile immune responses: implications for COVID-19 therapy	2020-04-09		.txt	text/plain	4121	208	46	Increasing evidence supports the notion that mortality during infections with SARS-CoV-2, which causes coronavirus disease of 2019 , is driven by the exacerbated immune response to the virus, leading to a cascade of events involving a cytokine storm and acute respiratory distress syndrome (ARDS), often accompanied by myocardial damage and multiple organ failure (5, 6) . Overall, these results have potential far-reaching significance for the treatment of COVID-19, justifying a deeper study of JAK inhibitors as a therapeutic strategy to attenuate the cytokine storm and downstream organ failure in this condition, while also indicating that individuals with DS should be considered a high-risk population during the COVID-19 pandemic. This analysis revealed that Dp16 mice have increased liver pathology even before P(I:C) treatment, as demonstrated by significantly higher levels of cell injury, inflammation, and reactive changes relative to their WT littermates (Figure 4B,C) .	./cache/cord-321050-yabt72jf.txt	./txt/cord-321050-yabt72jf.txt