id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-321369-xzu2faol	Andreano, Emanuele	Extremely potent human monoclonal antibodies from convalescent Covid-19 patients	2020-10-07		.txt	text/plain	3685	192	52	By single cell sorting 4277 SARS-CoV-2 spike protein specific memory B cells from 14 Covid-19 survivors, 453 neutralizing antibodies were identified and 220 of them were expressed as IgG. The three most potent monoclonal antibodies identified were able to neutralize the wild type and D614G mutant viruses with less than 10 ng/mL and are good candidates for the development of prophylactic and therapeutic tools against SARS-CoV-2. As for the authentic virus neutralization assay, supernatants containing naturally produced IgG or IgA were tested for their ability to protect the layer of Vero E6 cells from the cytopathic effect triggered by SARS-CoV-2 infection (Fig. S2) . This work describes a systematic screening of memory B cells from convalescent people to identify extremely potent human monoclonal antibodies against the spike protein of the SARS-CoV-2 virus, to be used for prevention and therapy of Covid-19.	./cache/cord-321369-xzu2faol.txt	./txt/cord-321369-xzu2faol.txt