id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-322654-6nccarjn	Luzes, Rafael	Angiotensin-(3–4) modulates angiotensin converting enzyme 2 (ACE2) downregulation in proximal tubule cells due to overweight and undernutrition: implications regarding the severity of renal lesions in Covid-19 infection	2020-06-29		.txt	text/plain	1447	89	52	title: Angiotensin-(3–4) modulates angiotensin converting enzyme 2 (ACE2) downregulation in proximal tubule cells due to overweight and undernutrition: implications regarding the severity of renal lesions in Covid-19 infection Since the renin-angiotensin-aldosterone system (RAAS) has been implicated in the progress of kidney failure during Covid-19, we also investigated the influence of Angiotensin-(3–4) (Ang-(3–4)) the shortest angiotensin-derived peptide, which is considered the physiological antagonist of several angiotensin II effects. That Ang-(3-4)-mediated upregulation of renal ACE2 126 occurred in overweight rats, but not in the CTR group, is indicative that a "pro-127 hypertensive tissular microenvironment" (high Ang II) develops in animals fed with a 128 diet rich in lipids, causing downregulation of ACE2 (Figure 2A The influence of chronic undernutrition on renal ACE2 levels present some 132 similarity, but also a huge difference, compared with overweight rats (Figure 3) .	./cache/cord-322654-6nccarjn.txt	./txt/cord-322654-6nccarjn.txt