id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-323041-wf0hlhim	Larsen, Mads Delbo	Afucosylated immunoglobulin G responses are a hallmark of enveloped virus infections and show an exacerbated phenotype in COVID-19	2020-05-18		.txt	text/plain	1413	92	56	Here, we report that afucosylated IgG which are of minor abundance in humans (∼6% of total IgG) are specifically formed against surface epitopes of enveloped viruses after natural infections or immunization with attenuated viruses, while protein subunit immunization does not elicit this low fucose response. Moreover, we have reported the lowered IgG-Fc fucosylation to be one of the factors 58 determining disease severity in pregnancy associated alloimmunizations, resulting in 59 excessive thrombocytopenia's and blood cell destruction when targeted by afucosylated 60 antibodies (11-13). 109 Analogous to the platelet and Red Blood cell alloantigens (10-12, 18), the response to these 110 enveloped viruses also showed significant afucosylation of the antigen-specific IgG (Fig.2B) , 111 while the afucosylation was absent against the non-enveloped virus Parvo B19 (Fig.2C ). Regulated glycosylation patterns of IgG during alloimmune 405 responses against human platelet antigens	./cache/cord-323041-wf0hlhim.txt	./txt/cord-323041-wf0hlhim.txt