id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-326380-9ecsp66y	Griesemer, Sara B	Assessment of sample pooling for clinical SARS-CoV-2 testing	2020-05-27		.txt	text/plain	2234	113	52	The greatest concern with this approach in a clinical setting is the potential for reduced sensitivity, particularly the risk of false negative results when weak positive samples are pooled. To investigate this possibility, detection rates in pooled samples were evaluated, with extensive assessment of pools containing weak positive specimens. Additionally, the percentage of positive samples at different viral loads, as assessed by Ct value, was reviewed across nine weeks of the pandemic, to determine if these weak positive specimens comprise a significant component of total tested specimens and whether the proportion has changed over the course of the pandemic. In contrast, for weak positive specimens in VTM transport media, nine-sample pools caused multiple replicates to return negative results. We then sought to assess what component of the total specimens tested are comprised of these weak positive specimens, to evaluate how much of an impact pooling might have overall on testing sensitivity across positive patient detection in the pandemic.	./cache/cord-326380-9ecsp66y.txt	./txt/cord-326380-9ecsp66y.txt