id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-326666-melz5fq4	Sun, Weitao	The discovery of gene mutations making SARS-CoV-2 well adapted for humans: host-genome similarity analysis of 2594 genomes from China, the USA and Europe	2020-09-03		.txt	text/plain	1723	138	62	title: The discovery of gene mutations making SARS-CoV-2 well adapted for humans: host-genome similarity analysis of 2594 genomes from China, the USA and Europe This study shows that the host-genome similarity (HGS) of SARS-CoV-2 is significantly higher than that of SARS-CoV, especially in the ORF6 and ORF8 genes encoding proteins antagonizing innate immunity in vivo. This finding implies that high HGS of SARS-CoV-2 genome may further inhibit IFN I synthesis and cause delayed host innate immunity. An ORF1ab mutation, 10818G>T, which occurred in virus populations with high HGS but rarely in low-HGS populations, was identified in 2594 genomes with geolocations of China, the USA and Europe. 578 shown with special markers at the top of colored blocks representing ORFs. Mutation 623 10818G>T in ORF1ab (codon TTG>TTT) occurred in populations with high HGS, which 624 results in amino acid M37F mutation in transmembrane protein nsp6. ORF1ab (codon TTG>TTT) occurred in populations with high HGS, which results in amino 631 acid M37F mutation in transmembrane protein nsp6.	./cache/cord-326666-melz5fq4.txt	./txt/cord-326666-melz5fq4.txt