id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-327520-qj7coqfr	Wei, Yulong	Coronavirus genomes carry the signatures of their habitats	2020-06-13		.txt	text/plain	1395	93	54	Coronaviruses such as SARS-CoV-2 regularly infect host tissues that express antiviral proteins (AVPs) in abundance. Two AVPs that may shape viral genomes are the zinc finger antiviral protein (ZAP) and the apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3 protein (APOBEC3). We tested the hypothesis that both APOBEC3 and ZAP may act as primary selective pressures that shape the genome of an infecting coronavirus by considering a comprehensive number of publicly available genomes for seven coronaviruses (SARS-CoV-2, SARS-CoV, MERS, Bovine CoV, Murine MHV, Porcine HEV, and Canine CoV). In SARS-CoV-2, CpG is most deficient in the S protein region to evaded ZAP-mediated antiviral defense during cell entry. Here we compared the CpG and U content 327 of these coronaviruses and found that viruses that regularly infect AVP-rich tissues tend to Based on global sequence comparison, figure 4a shows that most SNPs are C->U substitutions.	./cache/cord-327520-qj7coqfr.txt	./txt/cord-327520-qj7coqfr.txt