id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-328073-bqeffvzl	Limonta, Daniel	Nodosome inhibition as a novel broad-spectrum antiviral strategy against arboviruses and SARS-CoV-2	2020-11-06		.txt	text/plain	1878	113	55	The studies were prompted by the observation that infection of human fetal brain cells with Zika virus (ZIKV) induces expression of nucleotide-binding oligomerization domain-containing protein 2 (NOD2), a host factor that was found to promote ZIKV replication and spread. A drug that targets NOD2 was shown to have potent broad-spectrum antiviral activity against other flaviviruses, alphaviruses and SARS-CoV-2, the causative agent of COVID-19. Next, we demonstrated that the NOD2 inhibitor GSK717 blocks infection by and 205 spread of ZIKV in human fetal brain and cell lines. Similarly, the work here which demonstrated the antiviral activity of NOD2 and RIPK2 inhibitors using tissue explants, 216 primary cells and cell lines, support the potential clinical use of these compounds in mono or co-217 infections by arboviruses as well as coronavirus infections at early and/or advanced stages. Calu-3 and Huh7 cells infected with SARS-CoV-2 (MOI=0.1) were also treated with GSK583 for 24 hours before collecting the cell supernatants for viral titer determination.	./cache/cord-328073-bqeffvzl.txt	./txt/cord-328073-bqeffvzl.txt