id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-328257-kl4wh2zg	Xu, H	Hydroxychloroquine increased psychiatric-like behaviors and disrupted the expression of related genes in the mouse brain	2020-09-28		.txt	text/plain	4851	217	54	Although this animal study does not prove that HCQ has a similar effect in humans, it indicates that HCQ poses a significant risk to mental health and suggests that further clinical investigation is essential. Less attention has been paid to the effects of HCQ on mental health, although multiple studies have reported severe psychiatric symptoms, including agitation, hallucinations, anxiety, depression, and suicidal ideation, in patients treated with HCQ or chloroquine (9) (10) (11) (12) . To the best of our knowledge, this study is the first to test the psychiatric effect of HCQ in an animal model, and our results suggest that, in healthy mice, HCQ administration can induce persistent behavioral changes and disrupt gene expression in the brain. Our results did not reveal a significant effect of HCQ treatment on working memory, but total exploration time was decreased after HCQ administration, which also suggests that the drugs increased anxiety.	./cache/cord-328257-kl4wh2zg.txt	./txt/cord-328257-kl4wh2zg.txt