id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-330337-d41imvo7	Basu, Souradip	Impact of clade specific mutations on structural fidelity of SARS-CoV-2 proteins	2020-10-20		.txt	text/plain	6428	311	52	Our observations and analysis direct us to identify that all the major mutations have a negative impact in context of stability of the viral proteins under study and the mutant proteins suffer both structural and functional alterations as a result of the mutations. The secondary structure of the wild type and the mutant proteins along with their degree of disordered residues and accessible surface area was predicted using the primary sequence of the protein. Each of the seven proteins were assigned a score of either '-1' or '0', for each of the four computational tools used for epitope prediction, where '-1' corresponds to any change in number or binding efficacy of antigenic determinants, that may have surfaced because of mutation and '0' corresponds to no changes between wild type and mutant forms. I-Mutant2.0: predicting stability changes upon mutation from the protein sequence or structure	./cache/cord-330337-d41imvo7.txt	./txt/cord-330337-d41imvo7.txt