id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-332185-a96r1k7a	Zhang, Shuyuan	Bat and pangolin coronavirus spike glycoprotein structures provide insights into SARS-CoV-2 evolution	2020-09-22		.txt	text/plain	1228	103	63	title: Bat and pangolin coronavirus spike glycoprotein structures provide insights into SARS-CoV-2 evolution Here we determined the cryo-EM structures of the spikes from bat (RaTG13) and pangolin (PCoV_GX) coronaviruses, which are closely related to SARS-CoV-2. However, we found that the PCoV_GX, but not the RaTG13, spike is comparable to the SARS-CoV-2 spike in binding the human ACE2 receptor and supporting pseudovirus cell entry. Through structure and sequence comparisons, we identified critical residues in the RBD that underlie the different activities of the RaTG13 and PCoV_GX/SARS-CoV-2 spikes and propose that N-linked glycans serve as conformational control elements of the RBD. Cryo-electron microscopy structures of the SARS-CoV spike 464 glycoprotein reveal a prerequisite conformational state for receptor binding Cryo-EM structure of the SARS 467 coronavirus spike glycoprotein in complex with its host cell receptor ACE2 Cryo-EM structures of MERS-CoV and SARS-CoV spike 495 glycoproteins reveal the dynamic receptor binding domains	./cache/cord-332185-a96r1k7a.txt	./txt/cord-332185-a96r1k7a.txt