id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-332271-slouuryl	Baker, Jeremy D.	A drug repurposing screen identifies hepatitis C antivirals as inhibitors of the SARS-CoV-2 main protease	2020-08-27		.txt	text/plain	2683	172	52	title: A drug repurposing screen identifies hepatitis C antivirals as inhibitors of the SARS-CoV-2 main protease Here we show the existing pharmacopeia contains many drugs with potential for therapeutic repurposing 27 as selective and potent inhibitors of SARS-CoV-2 Mpro. Taken together this work suggests previous large-scale commercial 35 drug development initiatives targeting hepatitis C NS3/4A viral protease should be revisited because some 36 previous lead compounds may be more potent against SARS-CoV-2 Mpro than Boceprevir and suitable for 37 rapid repurposing. Taken together this work suggests previous large-scale commercial 35 drug development initiatives targeting hepatitis C NS3/4A viral protease should be revisited because some 36 previous lead compounds may be more potent against SARS-CoV-2 Mpro than Boceprevir and suitable for 37 rapid repurposing. Before screening the Broad library, 100 we piloted our assay conditions against the NIH Clinical collections library (~650 compounds) and 101 calculated our Z'-factor for each plate at 0.780 and 0.784 (Fig 1C and D) .	./cache/cord-332271-slouuryl.txt	./txt/cord-332271-slouuryl.txt