id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-334584-xh41koro	Dilucca, Maddalena	Temporal evolution and adaptation of SARS-COV 2 codon usage	2020-05-29		.txt	text/plain	3955	210	56	Thus, we compared the codon usage patterns, every two weeks, of 13 of SARS-CoV-2 genes encoding for the membrane protein (M), envelope (E), spike surface glycoprotein (S), nucleoprotein (N), non-structural 3C-like proteinase (3CLpro), ssRNA-binding protein (RBP), 2'-O-ribose methyltransferase (OMT), endoRNase (RNase), helicase, RNA-dependent RNA polymerase (RdRp), Nsp7, Nsp8, and exonuclease ExoN. An EN C plot analysis was performed to estimate the relative contributions of mutational bias and natural selection in shaping CUB of 13 genes encoding proteins that are crucial for SARS-CoV-2. For the funtionally important genes in each genome, we calculated the average values of CAI and ENC over time, as compared to the reference SARS-CoV-2 sequence (WSM). Based on the SiD combined with the CAI results ( Figure 5 ), we suggest that SARS-CoV-2, over time, has preferentially accumulated mutations in its genome which correspond to codons that adapt better to the human host.	./cache/cord-334584-xh41koro.txt	./txt/cord-334584-xh41koro.txt