id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-334891-4jgtxg07	Choudhury, Abhigyan	In silico analyses on the comparative sensing of SARS-CoV-2 mRNA by intracellular TLRs of human	2020-11-11		.txt	text/plain	2926	169	54	This study is hoped to rationalize the comparative binding and sensing of SARS-CoV-2 mRNA towards the intracellular TLRs, considering the solvent-based force-fields operational in the cytosolic aqueous microenvironment that predominantly drive these reactions. Our in-silico study on the binding of all mRNAs with the intracellular TLRs shown that the mRNA of NSP10, S2, and E proteins of SARS-CoV-2 are potent enough to bind with TLR3, TLR9, and TLR7 and trigger downstream cascade reactions, and may be used as an option for validation of therapeutic option and immunomodulation against COVID-19. The binding of Spike protein with the human ACE2 receptor triggers the pathogenesis 3 of the SARS-CoV-2, leading to the activation of TLRs to activate the proliferation and 4 production of pro-inflammatory cytokines causing cytokine storm, those results in 5 inflammations.	./cache/cord-334891-4jgtxg07.txt	./txt/cord-334891-4jgtxg07.txt