id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-336522-y9nzsv95	Rosenke, Kyle	Inhibition of SARS-CoV-2 in Vero cell cultures by peptide-conjugated morpholino-oligomers	2020-09-30		.txt	text/plain	1723	121	54	title: Inhibition of SARS-CoV-2 in Vero cell cultures by peptide-conjugated morpholino-oligomers Cell viability was 33 evaluated with an ATP-based method and viral growth was measured with quantitative RT-PCR 34 and TCID50 infectivity assays. Results: PPMO designed to base-pair with sequence in the 5'-terminal region or the leader 36 transcription regulatory sequence-region of SARS-CoV-2 genomic RNA were highly 37 efficacious, reducing viral titers by up to 4-6 log10 in cell cultures at 48-72 hours post-infection, 38 in a non-toxic and dose-responsive manner. Results: PPMO designed to base-pair with sequence in the 5'-terminal region or the leader 36 transcription regulatory sequence-region of SARS-CoV-2 genomic RNA were highly 37 efficacious, reducing viral titers by up to 4-6 log10 in cell cultures at 48-72 hours post-infection, 38 in a non-toxic and dose-responsive manner. In this study, five PPMO were designed to target the 5' UTR 107 and first translation start site-region of SARS-CoV-2 positive sense genomic RNA ( Table 1) .	./cache/cord-336522-y9nzsv95.txt	./txt/cord-336522-y9nzsv95.txt