id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-336628-0evl3wnd	Neufeldt, Christopher J.	SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-κB	2020-07-21		.txt	text/plain	5880	362	49	Consistently, secreted cytokine profiles from both severe COVID-19 patients and SARS-CoV-2 infected lung epithelial cells, were enriched for pro-inflammatory cytokines and lacked type I/III IFNs. We also demonstrate that SARS-CoV-2 infection leads specifically to NF-κB but not IRF3 nuclear localization and that poly(I:C)-induced pathway activation is attenuated in infected cells. To confirm that the lack of IFN response in Calu-3 or A549-ACE2 cells infected with SARS-CoV-2 was not due to defects in the activation of innate immune pathways, we To test if IFNs could limit virus replication even after establishment of infection, A549-ACE2 cells were treated with high levels of various IFNs at the time point of infection or 6 h thereafter. these results indicate that SARS-CoV2-infection triggers the cGAS-STING pathway, leading to NF-κB-mediated induction of pro-inflammatory cytokines, and that this response can be controlled with STING inhibitors.	./cache/cord-336628-0evl3wnd.txt	./txt/cord-336628-0evl3wnd.txt