id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-338296-2hk7h132	Malla, Tek Narsingh	Ebselen Reacts with SARS Coronavirus-2 Main Protease Crystals	2020-08-23		.txt	text/plain	490	47	71	title: Ebselen Reacts with SARS Coronavirus-2 Main Protease Crystals The SARS coronavirus 2 main protease 3CLpro tailor cuts various essential virus proteins out of long poly-protein translated from the virus RNA. Any compound that inhibits the 3CLpro is therefore a potential drug to end the pandemic. Here we show that the diffraction power of 3CLpro crystals is effectively destroyed by Ebselen. Apart from the fragments, the most promising compounds are the α-ketoamides (Fig. 1) 24 which bind tightly to the 3CLpro 1-3 . SARS CoV-2 3CLpro in its functional, dimeric form 1 . expensive, but also less known compound that binds to the 3CLpro is Ebselen 4 . Ebselen has been shown 29 to bind strongly to the CoV-2 3CLpro 4 , but the structure of the complex is unknown. show what happens when Ebselen is added to 3CLpro crystals. Accordingly, the structure of only the untreated 3CLpro can be solved.	./cache/cord-338296-2hk7h132.txt	./txt/cord-338296-2hk7h132.txt