id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-338543-q6cl5kjp	Salguero, Francisco J.	Comparison of Rhesus and Cynomolgus macaques as an authentic model for COVID-19	2020-09-17		.txt	text/plain	1093	59	56	Here, we show that SARS-CoV-2 replicates in the upper and lower respiratory tract and causes pulmonary lesions in both rhesus and cynomolgus macaques, resembling the mild clinical cases of COVID-19 in humans. In contrast to prior publications, in which rhesus are accepted to be the optimal study species, we provide convincing evidence that both macaque species authentically represent mild to moderate forms of COVID-19 observed in the majority of the human population and both species should be used to evaluate the safety and efficacy of novel and repurposed interventions against SARS-CoV-2. Throat swabs from cynomolgus macaques contained 147 higher levels of viral RNA early in infection (one to three dpc) and remained ≥4.5 x 148 10 4 copies/ml for all animals between four and nine dpc. However viral RNA 159 levels above the LLOQ were detected at both three dpc and five dpc in cynomolgus 160 macaques in comparison to two dpc and three dpc in rhesus macaques ( Figure 2D ).	./cache/cord-338543-q6cl5kjp.txt	./txt/cord-338543-q6cl5kjp.txt