id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-339720-d1stzy8w	Zhao, Yuan	Susceptibility of tree shrew to SARS-CoV-2 infection	2020-04-30		.txt	text/plain	2572	180	58	No clinical signs were observed in SARS-CoV-2 inoculated tree shrews during this experiment except the increasing body temperature (above 39° C) particular in female animals during infection. In three young tree shrews (TS26, TS27 and TS28), we could detect viral RNA from only lungs in TS26 and TS27, but not in any tissue from TS28, although these animal had higher number of viral genomic copy numbers at the earlier stage of SARS-CoV-2 infection. Although SARS-CoV-2 infection didn't cause severe disease in all three ages of tree shrews, viral replication and mild histopathological changes were still observed in this study. In conclusion, tree shrew is not as susceptible to SARS-CoV-2 infection as the reported animal models of COVID-19, though limited replication of SARS-CoV-2 and mild histopathology was detected and observed in some tissues. Young Old Adult 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 Histopathological examination of affected tissues from SARS-CoV-2 infected tree shrews.	./cache/cord-339720-d1stzy8w.txt	./txt/cord-339720-d1stzy8w.txt