id author title date pages extension mime words sentences flesch summary cache txt cord-341768-k86gsfng Suresh, Voddu Tissue distribution of ACE2 protein in Syrian golden hamster (Mesocricetus auratus) and its possible implications in SARS-CoV-2 related studies 2020-06-29 .txt text/plain 2541 141 45 title: Tissue distribution of ACE2 protein in Syrian golden hamster (Mesocricetus auratus) and its possible implications in SARS-CoV-2 related studies The major objective of our current study was to analyze the tissue-specific expression pattern of angiotensinâ–ˇconverting enzyme 2 (ACE2), a proven functional receptor for SARS-CoV-2 in different organs of the hamster. Certain earlier studies have shown expression of ACE2 transcripts or protein by lung epithelial cells [15] [16] [17] [18] , hence, just after the reports that ACE2 binds with SARS-CoV-2 spike (S) protein, the research and clinical communities assumed that high level of ACE2 expression in lung or other part of the respiratory tract might be a major driving factor in the pathogenesis of this respiratory virus. High expression of ACE2 in the kidney is believed to contribute to SARS-CoV-2 virus pathogenesis and disease severity 22 In our analysis, in addition to kidney and different parts of the gut, brain, liver, tongue are three other extra-pulmonary organs that showed ACE2 expression (Figure 1, 3 & 4) . ./cache/cord-341768-k86gsfng.txt ./txt/cord-341768-k86gsfng.txt