id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-342010-5mkf67os	Levasseur, Anthony	Genomic diversity and evolution of coronavirus (SARS-CoV-2) in France from 309 COVID-19-infected patients	2020-09-04		.txt	text/plain	5348	975	103	title: Genomic diversity and evolution of coronavirus (SARS-CoV-2) in France from 309 COVID-19-infected patients cord_uid: 5mkf67os The evolution and mutational events of the SARS-CoV-2 genomes are critical for controlling virulence, transmissibility, infectivity, severity of symptoms and mortality associated to this infectious disease. We collected and investigated 309 SARS-CoV-2 genomes from patients infected in France. Detailed genome cartography of all mutational events (SNPs, indels) was reported and correlated to clinical features of patients. A comparative analysis between our 309 SARS-CoV-2 genomes from French patients and the reference Wuhan coronavirus genome revealed 315 substitution mutations and six deletion events: ten were in 5'/3' UTR, 178 were nonsynonymous, 126 were synonymous and one generated a stop codon. Clinical outcomes of the 309 COVID-19-infected patients were investigated according to the mutational signatures of viral variants. Inclusion of the French cohort enabled us to identify 161 novel mutations never reported in SARS-CoV-2 genomes collected worldwide.	./cache/cord-342010-5mkf67os.txt	./txt/cord-342010-5mkf67os.txt