id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-342599-558yn6pu	Rinchai, Darawan	A modular framework for the development of targeted Covid-19 blood transcript profiling panels	2020-05-22		.txt	text/plain	5230	298	42	Here we aimed to develop an approach to support the design of focused blood transcriptome panels for profiling the immune response to SARS-CoV-2 infection. As a proof of principle, we designed three targeted blood transcript panels, each with a different translational connotation: therapeutic development relevance, SARS biology relevance and immunological relevance. In this proof of principle study, we used the available transcript profiling data from two separate studies to select Covid-19 relevant sets of modules (8, 9) . One of these applications provides access to module-level transcript abundance profiles for available Covid-19 blood transcriptome profiling datasets. Despite large differences between the two studies in terms of design, range of clinical severity, technology platforms and module coverage, the combined overall changes (detected at a high-level perspective) are consistent with those observed in known acute infections, such as those caused by influenza, respiratory syncytial virus (RSV) or S.	./cache/cord-342599-558yn6pu.txt	./txt/cord-342599-558yn6pu.txt