id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-343476-0chuwvg6	MacLean, Oscar A.	Evidence of significant natural selection in the evolution of SARS-CoV-2 in bats, not humans	2020-05-29		.txt	text/plain	1386	73	51	Here we contrast the role of positive selection and recombination in the Sarbecoviruses in horseshoe bats to SARS-CoV-2 evolution in humans. While methods can detect some evidence for positive selection in SARS-CoV-2, we demonstrate these are mostly due to recombination and sequencing artefacts. For all but two of the ten positive selected codons, this signal was being driven by apparent convergent evolution (or homoplasy) in the tree, with the same mutation occurring in parallel across the phylogeny. To investigate whether this observation was truly due to independent events or because of recombination signatures in the SARS-CoV-2 outbreak tree, we firstly determined if the samples with these convergent mutations were geographically correlated. The Spike V367F signal was driven by apparent convergent evolution between four french samples sequenced in January and a Hong Kong sample 412028, which shows shared variation either side of the homoplasy suggesting it is not a recombinant (Supplementary figure 3C) .	./cache/cord-343476-0chuwvg6.txt	./txt/cord-343476-0chuwvg6.txt