id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-344236-qp3ianzf	Ali, Fedaa	ACE2 coding variants in different populations and their potential impact on SARS-CoV-2 binding affinity	2020-05-08		.txt	text/plain	2465	163	54	Classical electrostatic calculations based on solving Poisson-Boltzmann (PB) equation is used to investigate the interaction energies between SARS-CoV-2 and ACE2 for different mutated ACE2 structures. In an attempt to better understand the susceptibility of different populations to infection by SARS-CoV-2, we gathered data on ACE2 missense variants from different projects and databases that aggregate allele frequencies (AF). These projects and databases included Single Nucleotide Polymorphism Database (dbSNP) 12, 13 , 1000 genomes project phase 3 (1KGP3) 14 , Allele Frequency Aggregator (ALFA project) a , Exome Aggregation Consortium (ExAC) 15 SARS-CoV-2 was reported to bind to human ACE2 via different ACE2 residues; Q24, D30, H34, Y41, Q42, M82, K353 and R357 5 . The electrostatic and the van der Waal contribution to the interaction energies of SARS-CoV-2/ACE2 were compared between single mutated and WT protein at pH =7 (Table 1 ).	./cache/cord-344236-qp3ianzf.txt	./txt/cord-344236-qp3ianzf.txt