id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-344909-0o55l4iy	Cross, Robert W.	Use of convalescent serum reduces severity of COVID-19 in nonhuman primates	2020-10-14		.txt	text/plain	5711	291	49	However, and importantly, lower levels of SARS-CoV-2 in respiratory compartments, reduced gross and histopathological lesion severity in the lungs, and reductions in several parameters associated with coagulation and inflammatory processes were observed in monkeys that received convalescent sera versus untreated controls. Differences in clinical parameters of the LD-treated group with untreated control animals from this study or historical control animals were minimal; however, the lack of infectious SARS-CoV-2 in the BAL samples from all of the LD-treated animals and reduced lung pathology suggest that an antiviral effect was present despite the lower concentration of neutralizing antibodies in the dose of convalescent sera administered. PRNT50 assays were performed on pooled convalescent sera from AGMs challenged with the homologous isolate of SARS-CoV-2 in previous studies (Cross et al., 2020; Woolsey et al., 2020) compared with control animals on day 2 post infection (d) and	./cache/cord-344909-0o55l4iy.txt	./txt/cord-344909-0o55l4iy.txt