id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-348159-v5hrcl5k	Sang, Eric R.	Epigenetic Evolution of ACE2 and IL-6 Genes as Non-Canonical Interferon-Stimulated Genes Correlate to COVID-19 Susceptibility in Vertebrates	2020-09-10		.txt	text/plain	2076	117	45	Furthermore, significantly higher positive histone modification markers and position weight matrix (PWM) scores of key cis-elements corresponding to inflammatory and IFN signaling, were discovered in both ACE2 and IL6 gene promoters across representative COVID-19-susceptible species compared to unsusceptible ones. Third, we found that the evolutionary increase of 147 ACE2, and especially the IL-6 genes response to inflammatory and IFN signaling may 148 serve as epigenetic marker for COVID-19 susceptibility in some animal species including 149 humans. . This shows that ACE2 and especially IL-6 genes from CoV2(+) species contain CREs with significantly higher mPWM scores, indicating that in some vertebrate species, non-ISGs like ACE2 and especially IL-6 genes evolved to obtain high inductive propensity by inflammatory and IFN signaling, and may serve as epigenetic biomarkers (or triggers) for susceptibility prediction for COVID-19 and other ARD syndromes.	./cache/cord-348159-v5hrcl5k.txt	./txt/cord-348159-v5hrcl5k.txt