id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-349364-vert186n	Márquez-López, Cristina	SARS-CoV-2 protein Nsp1 alters actomyosin cytoskeleton and phenocopies arrhythmogenic cardiomyopathy-related PKP2 mutant	2020-09-14		.txt	text/plain	5246	286	48	The fact that Nsp1 and PKP2 mutant R735X share similar phenotypes also suggests that direct SARS-CoV-2 heart infection could induce a transient ACM-like disease in COVID-19 patients, which may contribute to right ventricle dysfunction, observed in patients with poor survival prognosis. Using atomic force microscopy together with fluorescence imaging, we show that expression of PKP2 (c.2203C>T), encoding the R735X mutant found in ACM patients from different families (Alcalde et al., 2014; Gerull et al, 2004) alters cell mechanical stiffness, and alike Nsp1, modifies actomyosin cytoskeleton. All together, these results suggest that cytoplasmic localization of PKP2 either by a mutant involved in ACM development, or by Nsp1 hijack by SARS-CoV-2 infection can alter the integrity and assembly of the actin cytoskeleton by modulating the cortical distribution of Myh9 and Myh10.	./cache/cord-349364-vert186n.txt	./txt/cord-349364-vert186n.txt