id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-349684-2tioh80m	Pezzotti, Giuseppe	Rapid Inactivation of SARS-CoV-2 by Silicon Nitride, Copper, and Aluminum Nitride	2020-06-20		.txt	text/plain	5388	338	51	The present study compared the effects of exposing SARS-CoV-2 to aqueous suspensions of Si3N4 and aluminum nitride (AlN) particles and two controls, (i.e., a suspension of copper (Cu) particles (positive control) and a sham treatment (negative control)). In (c) and (d), results of RT-PCR tests for supernatants after 10 min exposure of virus suspension to Cu, AlN, and Si3N4 powders for viral N gene "set 1" and "set 2" primers are shown, respectively. The present work is the first to show that compounds capable of endogenous nitrogen-release, such as Si3N4 and AlN, can inactivate the SARS-CoV-2 virus at least as effectively as Cu. These results suggest that multiple antiviral mechanisms may be operative, such as RNA fragmentation, and in the case of Cu, direct metal ion toxicity; but while Cu and AlN supernatants demonstrated strong and partial cellular lysis, respectively, Si3N4 provoked no metabolic alterations.	./cache/cord-349684-2tioh80m.txt	./txt/cord-349684-2tioh80m.txt