id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-351559-az4pgi9k	Turjya, Rafeed Rahman	Perversely expressed long noncoding RNAs can alter host response and viral proliferation in SARS-CoV-2 infection	2020-06-29		.txt	text/plain	2438	173	48	Regulatory roles of long non-coding RNAs (lncRNAs) during viral infection and associated antagonism of host antiviral immune responses has become more evident in last decade. To elucidate possible functions of lncRNAs in the COVID-19 pathobiology, we have utilized RNA-seq dataset of SARS-CoV-2 infected lung epithelial cells. By network enrichment analysis we find that these lncRNAs can directly interact with differentially expressed protein-coding genes ADAR, EDN1, KYNU, MALL, TLR2 and YWHAG; and also AKAP8L, EXOSC5, GDF15, HECTD1, LARP4B, LARP7, MIPOL1, UPF1, MOV10 and PRKAR2A, host genes that interact with SARS-CoV-2 proteins. Conclusions Our investigation determines that deregulated lncRNAs in SARS-CoV-2 infection are involved in viral proliferation, cellular survival, and immune response, ultimately determining disease outcome and this information could drive the search for novel RNA therapeutics as a treatment option.	./cache/cord-351559-az4pgi9k.txt	./txt/cord-351559-az4pgi9k.txt