id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-353161-mtq6yh25	Rodrigues, João PGLM	Insights on cross-species transmission of SARS-CoV-2 from structural modeling	2020-06-05		.txt	text/plain	6169	369	56	We found that species known not to be susceptible to SARS-CoV-2 infection have non-conservative mutations in several ACE2 amino acid residues that disrupt key polar and charged contacts with the viral spike protein. Collectively, our results provide a structural framework that explains why certain animal species are not susceptible to SARS-CoV-2 infection, and also suggests potential mutations that can enhance binding to the viral RBD. Although it is well-known that docking scores do not quantitatively correlate with experimental binding affinities [19] , these scores suggest that SARS-CoV-2 neg species lack one or more key ACE2 residues that contribute significantly to the interaction with RBD. Models of SARS-CoV-2 neg species -chicken, duck, guinea pig, mouse, and rat -generally have higher (worse) HADDOCK scores than average (Figure 2 ), suggesting that these species' non-susceptibility to infection could stem from deficient RBD binding to ACE2.	./cache/cord-353161-mtq6yh25.txt	./txt/cord-353161-mtq6yh25.txt